ATX-304

ATX-304 is a cutting-edge pharmaceutical compound utilized primarily in the treatment of specific medical conditions which will be detailed below. This product is offered in a highly pure form as a lyophilized powder, ensuring stability and ease of formulation into various dosage forms. Each batch of Retatrutide is synthesized using advanced chemical processes to achieve the highest level of purity and consistency. As a leading pharmaceutical raw material supplier, Salispharm is committed to providing versatile active pharmaceutical ingredients (APIs) that can be tailored to a wide range of pharmaceutical applications.

A Phase 1b clinical trial reported in 2026 included 23 adults with obesity and prediabetes. Participants received oral ATX-304 400 mg daily for 8 weeks. Statistically significant improvements were observed in several metabolic markers:

Weight loss at this dose was modest. Researchers suggested that higher exposure may produce more pronounced metabolic effects in future studies. ATX-304 was generally well tolerated, with no reported adverse events related to core body temperature, heart rate, or flushing.

ATX-304 has entered Phase 2, with planned studies including REWIRE-1 (muscle function and lipid metabolism) and REWIRE-2 (muscle-preserving weight loss).

In preclinical models of progressive fatty liver disease, ATX-304 showed multiple metabolic benefits:

Reduced body fat mass

Lower blood cholesterol levels

Alleviated hepatic steatosis

Inhibited the development of liver fibrosis

Shifted metabolic programs toward increased fatty acid oxidation, reduced lipogenesis, and remodeled cholesterol/lipid transport

The study authors suggested that ATX-304 may be a potential therapeutic approach for MASLD.

In preclinical studies of cisplatin-induced acute kidney injury (CI-AKI), ATX-304 showed kidney-protective effects:

Improved renal function: serum creatinine was significantly lower in the ATX-304 pretreatment group (0.02 mM vs. 0.05 mM, P = 0.03).

Reduced injury markers: NGAL expression was significantly suppressed (1.2-fold vs. 3.3-fold, P = 0.002).

Less histological damage: kidney injury scores were significantly reduced (2.7 vs. 3.5, P = 0.03).

AMPK-dependent effect: protection was lost in AMPK-deficient cells, confirming that the effect depends on AMPK.

Metabolomic analysis showed changes in 66/126 metabolites in renal tubular epithelial cells, involving fatty acids, TCA cycle metabolites, and amino acids. Basal oxygen consumption rate increased by 38%, suggesting protection through metabolic reprogramming.

Our Retatrutide adheres to the highest quality standards and is certified by various international bodies, ensuring its safety and effectiveness:

FDA-Salis

HALAL

ISO

CCRE5

USDA Organic

EU Organic

Packaged under stringent conditions to maintain retatrutide powder integrity, It is available in multi-use vials to facilitate various dosing requirements. Our products are shipped with temperature control systems to ensure they arrive in perfect condition, irrespective of the destination.

General packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 5kg/carton(5kg net weight, 5.3kg gross weight, packed in five aluminum foil bag)

5)25kg/drum (25kg net weight, 28kg gross weight;)

Salispharm stands out as a top-tier provider in the pharmaceutical raw materials industry, distinguished by our robust capabilities and commitment to excellence. Here's why you should consider partnering with us:

Advanced R&D Capabilities: Our dedicated research and development team is committed to innovation and continuous improvement, ensuring that all products meet the highest standards of quality and efficacy.

State-of-the-Art Manufacturing: We operate a GMP-certified facility equipped with the latest technology for efficient and scalable production. This allows us to maintain high-quality standards and meet large-scale demands seamlessly.

Comprehensive Certifications: Salispharm is accredited with multiple international certifications such as GMP, ISO, and others, which underscore our commitment to meeting global compliance and quality standards.

Extensive Stock Levels: Our substantial inventory levels ensure that we can fulfill orders promptly, providing our clients with the products they need without delay.

Customization and Flexibility: We specialize in OEM services, offering custom dosage formulations and the ability to produce complete finished products tailored to the specific needs of our clients.

At Salispharm, we are eager to fulfill your custom pharmaceutical needs. For more information, quotes, or to discuss how we can support your projects,If you want to buy Retatrutide 5mg, or more please contact at sasha_slsbio@aliyun.com. We look forward to partnering with you to advance health care solutions globally.

Q1: Can i get some samples?
A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2: How to start orders or make payments?
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Escrow(Alibaba).

Q3: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the
samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q4:What's your MOQ?
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Q5: How about delivery lead time?
A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)