Pazopanib Hydrochloride Powder

product name:Pazopanib Hydrochloride Powder
Appearance: white powder
CAS No.: 635702-64-6
Formula:C21H24ClN7O2S
Function: Central nervous system cough suppressants
Country of origin: China
Grade: Pharmaceutical grade
Order lead time:7-15days
Payment method: T/T
MOQ:1kg
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Product Description

What is Pazopanib Hydrochloride Powder

  • Pazopanib Hydrochloride Powder is the hydrochloride salt form of Pazopanib, a tyrosine kinase inhibitor (TKI) used primarily as an anticancer drug.
  • Chemical Name: Pazopanib Hydrochloride
  • IUPAC Name: 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide monohydrochloride
  • Molecular Formula: C₂₁H₂₃N₇O₂·HCl
  • CAS No.: 635702-64-6
  • Appearance: Yellow to light yellow powder (hygroscopic).

Pazopanib Hydrochloride Powder

Effects of Pazopanib Hydrochloride Powder

Pazopanib Hydrochloride is a multi-targeted tyrosine kinase inhibitor (TKI) primarily used in oncology. Its effects can be categorized into therapeutic (beneficial) effects, side effects, and pharmacological mechanisms.

🔬 Primary Molecular Targets

VEGFR-1/2/3 (Vascular Endothelial Growth Factor Receptors) → Blocks tumor blood supply.

PDGFR-α/β (Platelet-Derived Growth Factor Receptors) → Inhibits stromal support.

c-Kit → Affects certain sarcomas and gastrointestinal stromal tumors (GIST).

🩺 Approved Clinical Uses

✅ Renal Cell Carcinoma (RCC) – First-line treatment for advanced kidney cancer.
✅ Soft Tissue Sarcoma (STS) – Used in advanced cases after chemotherapy failure.

📈 Efficacy

Prolongs progression-free survival (PFS) in RCC and STS.

Reduces tumor size in some patients (partial response).

2.Analgesic effect: Dextromethorphan hydrobromide has a certain analgesic effect. It relieves mild to moderate pains such as headaches, toothaches, joint pains, etc.

It reduces pain sensation and improves patient comfort.

3.Anti-inflammatory effect: Studies have found that dextromethorphan hydrobromide has certain anti-inflammatory effect. It suppresses the inflammatory response, reducing pain and discomfort caused by inflammation.

Effects of Pazopanib Hydrochloride Powder

COA of Pazopanib Hydrochloride

Items Specification Results
Appearance White Crystalline Powder Complies
Related substance (HPLC) Total impurity ≤0.5%Max 0.20%
Single impurity ≤0.1% 0.06%
Assay ≥99% 99.22%
Sieve analysis 100% pass 80 mesh Complies
Heavy Metal <10ppm Complies
As <0.1ppm 0.05ppm
Pb <0.1ppm 0.05ppm
Cd <0.1ppm 0.05ppm
Residual Solvents <100ppm Complies
Residual Pesticide Negative Complies
Total Plate Count <1000cfu/g Complies
Yeast & Mold <100cfu/g Complies
E.Coli Negative Negative
Salmonella Negative Negative

Packaging and Transportation:

At Salispharm, we focus on the no problem at all bundling of our items to guarantee their respectability during transportation. It is carefully loaded as per industry guidelines to forestall defilement and keep up with item steadiness. We offer an assortment of bundling choices to oblige different client needs and inclinations. Our effective strategies network empowers quick and dependable transportation of orders to objections around the world, guaranteeing ideal conveyance and consumer loyalty.

Dextromethorphan Hydrobromide

Contact US

If you want to buy Pazopanib Hydrochloride Powder please contact us for more details sasha_slsbio@aliyun.com