Pazopanib Hydrochloride Powder
product name：Pazopanib Hydrochloride Powder
Appearance: white powder
CAS No.: 635702-64-6
Formula:C21H24ClN7O2S
Function: Central nervous system cough suppressants
Country of origin: China
Grade: Pharmaceutical grade
Order lead time:7-15days
Payment method: T/T
MOQ:1kg
Appearance: white powder
CAS No.: 635702-64-6
Formula:C21H24ClN7O2S
Function: Central nervous system cough suppressants
Country of origin: China
Grade: Pharmaceutical grade
Order lead time:7-15days
Payment method: T/T
MOQ:1kg
Send Inquiry
Product Description
Product Description
What is Pazopanib Hydrochloride Powder
- Pazopanib Hydrochloride Powder is the hydrochloride salt form of Pazopanib, a tyrosine kinase inhibitor (TKI) used primarily as an anticancer drug.
- Chemical Name: Pazopanib Hydrochloride
- IUPAC Name: 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide monohydrochloride
- Molecular Formula: C₂₁H₂₃N₇O₂·HCl
- CAS No.: 635702-64-6
- Appearance: Yellow to light yellow powder (hygroscopic).
Effects of Pazopanib Hydrochloride Powder
Pazopanib Hydrochloride is a multi-targeted tyrosine kinase inhibitor (TKI) primarily used in oncology. Its effects can be categorized into therapeutic (beneficial) effects, side effects, and pharmacological mechanisms.
🔬 Primary Molecular Targets
VEGFR-1/2/3 (Vascular Endothelial Growth Factor Receptors) → Blocks tumor blood supply.
PDGFR-α/β (Platelet-Derived Growth Factor Receptors) → Inhibits stromal support.
c-Kit → Affects certain sarcomas and gastrointestinal stromal tumors (GIST).
🩺 Approved Clinical Uses
✅ Renal Cell Carcinoma (RCC) – First-line treatment for advanced kidney cancer.
✅ Soft Tissue Sarcoma (STS) – Used in advanced cases after chemotherapy failure.
📈 Efficacy
Prolongs progression-free survival (PFS) in RCC and STS.
Reduces tumor size in some patients (partial response).
2.Analgesic effect: Dextromethorphan hydrobromide has a certain analgesic effect. It relieves mild to moderate pains such as headaches, toothaches, joint pains, etc.
It reduces pain sensation and improves patient comfort.
3.Anti-inflammatory effect: Studies have found that dextromethorphan hydrobromide has certain anti-inflammatory effect. It suppresses the inflammatory response, reducing pain and discomfort caused by inflammation.
COA of Pazopanib Hydrochloride
| Items | Specification | Results |
|---|---|---|
| Appearance | White Crystalline Powder | Complies |
| Related substance (HPLC) | Total impurity ≤0.5%Max | 0.20% |
| Single impurity ≤0.1% | 0.06% | |
| Assay | ≥99% | 99.22% |
| Sieve analysis | 100% pass 80 mesh | Complies |
| Heavy Metal | <10ppm | Complies |
| As | <0.1ppm | 0.05ppm |
| Pb | <0.1ppm | 0.05ppm |
| Cd | <0.1ppm | 0.05ppm |
| Residual Solvents | <100ppm | Complies |
| Residual Pesticide | Negative | Complies |
| Total Plate Count | <1000cfu/g | Complies |
| Yeast & Mold | <100cfu/g | Complies |
| E.Coli | Negative | Negative |
| Salmonella | Negative | Negative |
Packaging and Transportation:
At Salispharm, we focus on the no problem at all bundling of our items to guarantee their respectability during transportation. It is carefully loaded as per industry guidelines to forestall defilement and keep up with item steadiness. We offer an assortment of bundling choices to oblige different client needs and inclinations. Our effective strategies network empowers quick and dependable transportation of orders to objections around the world, guaranteeing ideal conveyance and consumer loyalty.
Contact US
If you want to buy Pazopanib Hydrochloride Powder please contact us for more details sasha_slsbio@aliyun.com
